Peptides have become one of the most popular skincare ingredients for firmer, smoother-looking skin. They're also one of the few actives that are generally gentle enough to use soon after microneedling. Here's what peptides are, why they pair well with microneedling, and how to use them.
The short answer: peptides are short chains of amino acids that support smoother, firmer-looking skin. Unlike retinoids or acids, most are gentle and rarely irritating, so many people use them from the first day or two after microneedling. Apply them after hyaluronic acid and before moisturiser, and choose a fragrance-free formula.
What are peptides?
Peptides are small fragments of proteins, made of amino acids. Your skin uses proteins like collagen and elastin to stay firm and springy. In skincare, peptides are thought to act as messengers that support the skin's own renewal processes, or help with hydration and the skin barrier.
Common types of peptides
| Type | What it's used for |
|---|---|
| Signal peptides | Supporting firmer, smoother-looking skin |
| Copper peptides | Supporting skin renewal and a smoother look |
| "Expression line" peptides | Marketed for softening the look of expression lines |
| Carrier and barrier peptides | Supporting hydration and the skin barrier |
Evidence varies between peptides, and many studies are funded by ingredient manufacturers, so it's best to see peptides as a supportive, gentle addition rather than a miracle ingredient.
Why peptides pair well with microneedling
- Gentle. Most peptides are rarely irritating, so they suit freshly needled skin better than strong actives.
- Complementary. Microneedling encourages renewal; peptides support firm, smooth-looking skin day to day.
- Easy to layer with hyaluronic acid and moisturiser.
When to apply peptides
- Not as a glide. Use plain hyaluronic acid during your session.
- Straight after or the next day: many people apply a simple peptide serum after hyaluronic acid. If your skin is sensitive, wait until the next day.
- Copper peptides: these can be stronger. Wait 48 to 72 hours, and avoid using them in the same routine as vitamin C or acids.
- Every day: morning and evening, under moisturiser and SPF.
How to layer
- Gentle cleanser
- Hyaluronic acid
- Peptide serum
- Fragrance-free moisturiser
- SPF in the morning
Choosing a peptide serum
- Fragrance-free, with a short ingredient list
- No added acids, retinol or strong vitamin C
- Pump or dropper packaging
- Patch test before using it with microneedling
Building your routine with Olapen
Hyaluronic acid during your Olapen session, then peptides and moisturiser afterwards, is a simple, gentle routine. See what to put on your skin after microneedling for more.
Frequently asked questions
Can I use peptides after microneedling?
Most simple peptide serums are fine from the first day or two. Wait longer with copper peptides.
Are peptides better than retinol?
They're gentler, but retinol has stronger evidence. Many people use both, on different days.
Can I use peptides as a glide?
Use plain hyaluronic acid as your glide instead.
Can I use peptides with nanoneedling?
Yes, after hyaluronic acid. See the best serums for nanoneedling.
Do peptides work?
Evidence varies by peptide. They're a gentle, supportive addition to a routine.
The bottom line
Peptides are a gentle, easy partner for microneedling. Use hyaluronic acid as your glide, add a simple peptide serum afterwards, and keep stronger actives for later in the week.
Microneedling and nanoneedling are cosmetic procedures. They are not intended to diagnose, treat, cure or prevent any medical condition. If you have a skin condition or any concerns, speak to a healthcare professional.